AID induces intraclonal diversity and genomic damage in CD86(+) chronic lymphocytic leukemia cells

The activation-induced cytidine deaminase (AID) mediates somatic hypermutation and class switch recombination of the Ig genes by directly deaminating cytosines to uracils. As AID causes a substantial amount of off-target mutations, its activity has been associated with lymphomagenesis and clonal evo...

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Detalles Bibliográficos
Autores principales: Huemer, Michael, Rebhandl, Stefan, Zaborsky, Nadja, Gassner, Franz J, Hainzl, Stefan, Weiss, Lukas, Hebenstreit, Daniel, Greil, Richard, Geisberger, Roland
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Clinical Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4276288/
https://www.ncbi.nlm.nih.gov/pubmed/25179679
http://dx.doi.org/10.1002/eji.201344421

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4276288/
https://www.ncbi.nlm.nih.gov/pubmed/25179679
http://dx.doi.org/10.1002/eji.201344421

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