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AID induces intraclonal diversity and genomic damage in CD86(+) chronic lymphocytic leukemia cells

The activation-induced cytidine deaminase (AID) mediates somatic hypermutation and class switch recombination of the Ig genes by directly deaminating cytosines to uracils. As AID causes a substantial amount of off-target mutations, its activity has been associated with lymphomagenesis and clonal evo...

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Detalles Bibliográficos
Autores principales:	Huemer, Michael, Rebhandl, Stefan, Zaborsky, Nadja, Gassner, Franz J, Hainzl, Stefan, Weiss, Lukas, Hebenstreit, Daniel, Greil, Richard, Geisberger, Roland
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BlackWell Publishing Ltd 2014
Materias:	Clinical Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4276288/ https://www.ncbi.nlm.nih.gov/pubmed/25179679 http://dx.doi.org/10.1002/eji.201344421

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