Cargando…
Effects of chronic kidney disease and uremia on hepatic drug metabolism and transport
The pharmacokinetics of non-renally cleared drugs in patients with chronic kidney disease is often unpredictable. Some of this variability may be due to alterations in the expression and activity of extra-renal drug metabolizing enzymes and transporters, primarily localized in the liver and intestin...
| Autores principales: | , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2013
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4276411/ https://www.ncbi.nlm.nih.gov/pubmed/24132209 http://dx.doi.org/10.1038/ki.2013.399 |