S-Adenosyl-l-methionine-competitive inhibitors of the histone methyltransferase EZH2 induce autophagy and enhance drug sensitivity in cancer cells

The enhancer of zeste homolog 2 (EZH2) has emerged as a novel anticancer target. Various EZH2 inhibitors have been developed in recent years. Among these, 3-deazaneplanocin A (DZNep) is known to deplete EZH2 protein expression through an indirect pathway. In contrast, GSK343 directly inhibits enzyme...

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Detalles Bibliográficos
Autores principales: Liu, Tsang-Pai, Lo, Hsiang-Ling, Wei, Li-Shan, Hao-yun Hsiao, Heidi, Yang, Pei-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2015
Materias:
Preclinical Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4276571/
https://www.ncbi.nlm.nih.gov/pubmed/25203626
http://dx.doi.org/10.1097/CAD.0000000000000166

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4276571/
https://www.ncbi.nlm.nih.gov/pubmed/25203626
http://dx.doi.org/10.1097/CAD.0000000000000166

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