β(2)-Microglobulin Amyloid Fibrils Are Nanoparticles That Disrupt Lysosomal Membrane Protein Trafficking and Inhibit Protein Degradation by Lysosomes

Fragmentation of amyloid fibrils produces fibrils that are reduced in length but have an otherwise unchanged molecular architecture. The resultant nanoscale fibril particles inhibit the cellular reduction of the tetrazolium dye 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), a su...

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Detalles Bibliográficos
Autores principales: Jakhria, Toral, Hellewell, Andrew L., Porter, Morwenna Y., Jackson, Matthew P., Tipping, Kevin W., Xue, Wei-Feng, Radford, Sheena E., Hewitt, Eric W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2014
Materias:
Molecular Bases of Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4276847/
https://www.ncbi.nlm.nih.gov/pubmed/25378395
http://dx.doi.org/10.1074/jbc.M114.586222

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4276847/
https://www.ncbi.nlm.nih.gov/pubmed/25378395
http://dx.doi.org/10.1074/jbc.M114.586222

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