The Ubiquitin C-Terminal Hydrolase L1 (UCH-L1) C Terminus Plays a Key Role in Protein Stability, but Its Farnesylation Is Not Required for Membrane Association in Primary Neurons

Ubiquitin C-terminal hydrolase L1 (UCH-L1) is a deubiquitinating enzyme that is highly expressed in neurons. A possible role for UCH-L1 in neurodegeneration has been highlighted because of its presence in Lewy bodies associated with Parkinson disease and neurofibrillary tangles observed in Alzheimer...

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Detalles Bibliográficos
Autores principales: Bishop, Paul, Rubin, Philip, Thomson, Andrew R., Rocca, Dan, Henley, Jeremy M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2014
Materias:
Neurobiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4276877/
https://www.ncbi.nlm.nih.gov/pubmed/25326379
http://dx.doi.org/10.1074/jbc.M114.557124

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4276877/
https://www.ncbi.nlm.nih.gov/pubmed/25326379
http://dx.doi.org/10.1074/jbc.M114.557124

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