Monoclonal Antibodies Specific for STAT3β Reveal Its Contribution to Constitutive STAT3 Phosphorylation in Breast Cancer

Since its discovery in mice and humans 19 years ago, the contribution of alternatively spliced Stat3, Stat3β, to the overall functions of Stat3 has been controversial. Tyrosine-phosphorylated (p) Stat3β homodimers are more stable, bind DNA more avidly, are less susceptible to dephosphorylation, and...

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Detalles Bibliográficos
Autores principales: Bharadwaj, Uddalak, Kasembeli, Moses M., Eckols, T. Kris, Kolosov, Mikhail, Lang, Paul, Christensen, Kurt, Edwards, Dean P., Tweardy, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4276954/
https://www.ncbi.nlm.nih.gov/pubmed/25268166
http://dx.doi.org/10.3390/cancers6042012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4276954/
https://www.ncbi.nlm.nih.gov/pubmed/25268166
http://dx.doi.org/10.3390/cancers6042012

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