TP53 oncomorphic mutations predict resistance to platinum- and taxane-based standard chemotherapy in patients diagnosed with advanced serous ovarian carcinoma

Individual mutations in the tumor suppressor TP53 alter p53 protein function. Some mutations create a non-functional protein, whereas others confer oncogenic activity, which we term ‘oncomorphic’. Since mutations in TP53 occur in nearly all ovarian tumors, the objective of this study was to determin...

Descripción completa

Detalles Bibliográficos
Autores principales: BRACHOVA, PAVLA, MUETING, SAMUEL R., CARLSON, MATTHEW J., GOODHEART, MICHAEL J., BUTTON, ANNA M., MOTT, SARAH L., DAI, DONGHAI, THIEL, KRISTINA W., DEVOR, ERIC J., LESLIE, KIMBERLY K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2014
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4277253/
https://www.ncbi.nlm.nih.gov/pubmed/25385265
http://dx.doi.org/10.3892/ijo.2014.2747

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4277253/
https://www.ncbi.nlm.nih.gov/pubmed/25385265
http://dx.doi.org/10.3892/ijo.2014.2747

Ejemplares similares