CCR5 Gene Disruption via Lentiviral Vectors Expressing Cas9 and Single Guided RNA Renders Cells Resistant to HIV-1 Infection

CCR5, a coreceptor for HIV-1 entry, is a major target for drug and genetic intervention against HIV-1. Genetic intervention strategies have knocked down CCR5 expression levels by shRNA or disrupted the CCR5 gene using zinc finger nucleases (ZFN) or Transcription activator-like effector nuclease (TAL...

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Detalles Bibliográficos
Autores principales: Wang, Weiming, Ye, Chaobaihui, Liu, Jingjing, Zhang, Di, Kimata, Jason T., Zhou, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4277423/
https://www.ncbi.nlm.nih.gov/pubmed/25541967
http://dx.doi.org/10.1371/journal.pone.0115987

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4277423/
https://www.ncbi.nlm.nih.gov/pubmed/25541967
http://dx.doi.org/10.1371/journal.pone.0115987

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