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Upregulation of Unc-51-Like Kinase 1 by Nitric Oxide Stabilizes SIRT1, Independent of Autophagy

SIRT1 is central to the lifespan and vascular health, but undergoes degradation that contributes to several medical conditions, including diabetes. How SIRT1 turnover is regulated remains unclear. However, emerging evidence suggests that endothelial nitric oxide synthase (eNOS) positively regulates...

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Detalles Bibliográficos
Autores principales: Xing, Junhui, Liu, Hongtao, Yang, Huabing, Chen, Rui, Chen, Yuguo, Xu, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4277463/
https://www.ncbi.nlm.nih.gov/pubmed/25541949
http://dx.doi.org/10.1371/journal.pone.0116165