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Nanopores Discriminate among Five C5-Cytosine Variants in DNA

[Image: see text] Individual DNA molecules can be read at single nucleotide precision using nanopores coupled to processive enzymes. Discrimination among the four canonical bases has been achieved, as has discrimination among cytosine, 5-methylcytosine (mC), and 5-hydroxymethylcytosine (hmC). Two ad...

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Detalles Bibliográficos
Autores principales: Wescoe, Zachary L., Schreiber, Jacob, Akeson, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4277752/
https://www.ncbi.nlm.nih.gov/pubmed/25347819
http://dx.doi.org/10.1021/ja508527b