Modeling Linear and Cyclic PKS Intermediates through Atom Replacement

[Image: see text] The mechanistic details of many polyketide synthases (PKSs) remain elusive due to the instability of transient intermediates that are not accessible via conventional methods. Here we report an atom replacement strategy that enables the rapid preparation of polyketone surrogates by...

Descripción completa

Detalles Bibliográficos
Autores principales: Shakya, Gaurav, Rivera, Heriberto, Lee, D. John, Jaremko, Matt J., La Clair, James J., Fox, Daniel T., Haushalter, Robert W., Schaub, Andrew J., Bruegger, Joel, Barajas, Jesus F., White, Alexander R., Kaur, Parminder, Gwozdziowski, Emily R., Wong, Fiona, Tsai, Shiou-Chuan, Burkart, Michael D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4277753/
https://www.ncbi.nlm.nih.gov/pubmed/25406716
http://dx.doi.org/10.1021/ja5064857

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4277753/
https://www.ncbi.nlm.nih.gov/pubmed/25406716
http://dx.doi.org/10.1021/ja5064857

Ejemplares similares