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Tubulin Bond Energies and Microtubule Biomechanics Determined from Nanoindentation in Silico

[Image: see text] Microtubules, the primary components of the chromosome segregation machinery, are stabilized by longitudinal and lateral noncovalent bonds between the tubulin subunits. However, the thermodynamics of these bonds and the microtubule physicochemical properties are poorly understood....

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Detalles Bibliográficos
Autores principales: Kononova, Olga, Kholodov, Yaroslav, Theisen, Kelly E., Marx, Kenneth A., Dima, Ruxandra I., Ataullakhanov, Fazly I., Grishchuk, Ekaterina L., Barsegov, Valeri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4277772/
https://www.ncbi.nlm.nih.gov/pubmed/25389565
http://dx.doi.org/10.1021/ja506385p