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Manipulation of Endogenous Kinase Activity in Living Cells Using Photoswitchable Inhibitory Peptides
[Image: see text] Optogenetic control of endogenous signaling can be an important tool for probing cell behavior. Using the photoresponse of the LOV2 domain of Avena sativa phototropin 1, we developed analogues of kinase inhibitors whose activity is light dependent. Inhibitory peptides were appended...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical
Society
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4277778/ https://www.ncbi.nlm.nih.gov/pubmed/24905630 http://dx.doi.org/10.1021/sb5001356 |