Testing non-inferiority of a new treatment in three-arm clinical trials with binary endpoints

BACKGROUND: A two-arm non-inferiority trial without a placebo is usually adopted to demonstrate that an experimental treatment is not worse than a reference treatment by a small pre-specified non-inferiority margin due to ethical concerns. Selection of the non-inferiority margin and establishment of...

Descripción completa

Detalles Bibliográficos
Autores principales: Tang, Nian-Sheng, Yu, Bin, Tang, Man-Lai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4277823/
https://www.ncbi.nlm.nih.gov/pubmed/25524326
http://dx.doi.org/10.1186/1471-2288-14-134

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4277823/
https://www.ncbi.nlm.nih.gov/pubmed/25524326
http://dx.doi.org/10.1186/1471-2288-14-134

Ejemplares similares