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Testing non-inferiority of a new treatment in three-arm clinical trials with binary endpoints

BACKGROUND: A two-arm non-inferiority trial without a placebo is usually adopted to demonstrate that an experimental treatment is not worse than a reference treatment by a small pre-specified non-inferiority margin due to ethical concerns. Selection of the non-inferiority margin and establishment of...

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Detalles Bibliográficos
Autores principales:	Tang, Nian-Sheng, Yu, Bin, Tang, Man-Lai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4277823/ https://www.ncbi.nlm.nih.gov/pubmed/25524326 http://dx.doi.org/10.1186/1471-2288-14-134

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