Cargando…

Modulation of CFTR gating by permeant ions

Cystic fibrosis transmembrane conductance regulator (CFTR) is unique among ion channels in that after its phosphorylation by protein kinase A (PKA), its ATP-dependent gating violates microscopic reversibility caused by the intimate involvement of ATP hydrolysis in controlling channel closure. Recent...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yeh, Han-I, Yeh, Jiunn-Tyng, Hwang, Tzyh-Chang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2015
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4278182/ https://www.ncbi.nlm.nih.gov/pubmed/25512598 http://dx.doi.org/10.1085/jgp.201411272

Ejemplares similares

Pharmacological Responses of the G542X-CFTR to CFTR Modulators
por: Fang, Xinxiu, et al.
Publicado: (2022)

Structural mechanisms of CFTR function and dysfunction
por: Hwang, Tzyh-Chang, et al.
Publicado: (2018)

Functional characterization reveals that zebrafish CFTR prefers to occupy closed channel conformations
por: Zhang, Jingyao, et al.
Publicado: (2018)

State-dependent modulation of CFTR gating by pyrophosphate
por: Tsai, Ming-Feng, et al.
Publicado: (2009)

A common mechanism for CFTR potentiators
por: Yeh, Han-I, et al.
Publicado: (2017)

Influence of Permeant Ions on Gating in Cyclic Nucleotide–gated Channels
por: Holmgren, Miguel
Publicado: (2003)

CFTR Gating I: Characterization of the ATP-dependent Gating of a Phosphorylation-independent CFTR Channel (ΔR-CFTR)
por: Bompadre, Silvia G., et al.
Publicado: (2005)

Nonintegral stoichiometry in CFTR gating revealed by a pore-lining mutation
por: Jih, Kang-Yang, et al.
Publicado: (2012)

Identification of a novel post-hydrolytic state in CFTR gating
por: Jih, Kang-Yang, et al.
Publicado: (2012)

Dual roles of the sixth transmembrane segment of the CFTR chloride channel in gating and permeation
por: Bai, Yonghong, et al.
Publicado: (2010)

Identifying the molecular target sites for CFTR potentiators GLPG1837 and VX-770
por: Yeh, Han-I, et al.
Publicado: (2019)

CFTR Gating II: Effects of Nucleotide Binding on the Stability of Open States
por: Bompadre, Silvia G., et al.
Publicado: (2005)

Mutations at the Signature Sequence of CFTR Create a Cd(2+)-gated Chloride Channel
por: Wang, Xiaohui, et al.
Publicado: (2009)

Permeant ion effects on the gating kinetics of the type L potassium channel in mouse lymphocytes
Publicado: (1991)

Permeant Ion-Dependent Changes in Gating of Kir2.1 Inward Rectifier Potassium Channels
por: Lu, Tao, et al.
Publicado: (2001)

Electrostatic tuning of the pre- and post-hydrolytic open states in CFTR
por: Zhang, Jingyao, et al.
Publicado: (2017)

G551D and G1349D, Two CF-associated Mutations in the Signature Sequences of CFTR, Exhibit Distinct Gating Defects
por: Bompadre, Silvia G., et al.
Publicado: (2007)

Of muscle modulation and the CFTR gate
por: Adler, Elizabeth M.
Publicado: (2015)

Probing an Open CFTR Pore with Organic Anion Blockers
por: Zhou, Zhen, et al.
Publicado: (2002)

The Two ATP Binding Sites of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Play Distinct Roles in Gating Kinetics and Energetics
por: Zhou, Zhen, et al.
Publicado: (2006)

On the mechanism of CFTR inhibition by a thiazolidinone derivative
por: Kopeikin, Zoia, et al.
Publicado: (2010)

Permeant calcium ion feed-through regulation of single inositol 1,4,5-trisphosphate receptor channel gating
por: Vais, Horia, et al.
Publicado: (2012)

Sodium channel selectivity. Dependence on internal permeant ion concentration
Publicado: (1976)

Spatial positioning of CFTR’s pore-lining residues affirms an asymmetrical contribution of transmembrane segments to the anion permeation pathway
por: Gao, Xiaolong, et al.
Publicado: (2016)

Single Channel Seeks Permeant Ion for Brief but Intimate Relationship
por: Yellen, Gary
Publicado: (1997)

The Relationship between Camp, Ca(2)+, and Transport of Cftr to the Plasma Membrane
por: Chen, Peng, et al.
Publicado: (2001)

A single amino acid substitution in CFTR converts ATP to an inhibitory ligand
por: Lin, Wen-Ying, et al.
Publicado: (2014)

Structural basis for the channel function of a degraded ABC transporter, CFTR (ABCC7)
por: Bai, Yonghong, et al.
Publicado: (2011)

Stable ATP binding mediated by a partial NBD dimer of the CFTR chloride channel
por: Tsai, Ming-Feng, et al.
Publicado: (2010)

Commentary Cystic Fibrosis Transmembrane Conductance Regulator : Permeant Ions Find the Pore
por: Dawson, David C., et al.
Publicado: (1997)

Anomalous Effect of Permeant Ion Concentration on Peak Open Probability of Cardiac Na(+) Channels
por: Townsend, Claire, et al.
Publicado: (1997)

Influence of Permeant Ions on Voltage Sensor Function in the Kv2.1 Potassium Channel
por: Consiglio, Joseph F., et al.
Publicado: (2004)

Tuning the Voltage Dependence of Tetraethylammonium Block with Permeant Ions in an Inward-Rectifier K(+) Channel
por: Spassova, Maria, et al.
Publicado: (1999)

Sensing its own permeant ion: KCNQ1 channel inhibition by external K(+)
por: Barro-Soria, Rene
Publicado: (2023)

Excitation of skinned muscle fibers by imposed ion gradients. III. Distribution of permeant ions in unstimulated and stimulated fibers
Publicado: (1989)

Membrane‐Permeant, Bioactivatable Coumarin Derivatives for In‐Cell Labelling
por: Schultz, Madeleine, et al.
Publicado: (2022)

Cell-Permeant and Photocleavable Chemical Inducer of Dimerization**
por: Zimmermann, Mirjam, et al.
Publicado: (2014)

New structural insights into the gating movements of CFTR
por: Puljung, Michael C.
Publicado: (2015)

CFTR gating: Invisible transitions made visible
por: Csanády, László
Publicado: (2017)

Gating of Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channels by Adenosine Triphosphate Hydrolysis : Quantitative Analysis of a Cyclic Gating Scheme
por: Zeltwanger, Shawn, et al.
Publicado: (1999)

Cannot write session to /tmp/vufind_sessions/sess_vcpscpb9js3ugt1kskdef6nht2