Mitomycin C reduces abundance of replication forks but not rates of fork progression in primary and transformed human cells

DNA crosslinks can block replication in vitro and slow down S phase progression in vivo. We characterized the effect of mitomycin C crosslinker on S phase globally and on individual replication forks in wild type and FANCD2-deficient human cells. FANCD2 is critical to crosslink repair, and is also i...

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Detalles Bibliográficos
Autores principales: Kehrli, Keffy, Sidorova, Julia M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4278321/
https://www.ncbi.nlm.nih.gov/pubmed/25580447

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4278321/
https://www.ncbi.nlm.nih.gov/pubmed/25580447

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