Up-regulation of anti-apoptotic genes confers resistance to the novel anti-leukaemic compound PEP005 in primary AML cells

We showed previously that PEP005 induced apoptosis in leukaemic cell lines and blasts from patients with acute myeloid leukaemia (AML). Here we assess the anti-leukeamic effects of PEP005 in vivo and determine the mechanism of resistance of PEP005 non-responsive cells. We used 2 human xenograft mous...

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Detalles Bibliográficos
Autores principales: Hampson, Peter, Wang, Keqing, Ersvær, Elisabeth, McCormack, Emmet, Schüler, Julia, Fiebig, Heinz-Herbert, Gjertsen, Bjørn Tore, Bruserud, Øystein, Lord, Janet M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4278328/
https://www.ncbi.nlm.nih.gov/pubmed/25594060

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4278328/
https://www.ncbi.nlm.nih.gov/pubmed/25594060

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