Enhancing In Silico Protein-Based Vaccine Discovery for Eukaryotic Pathogens Using Predicted Peptide-MHC Binding and Peptide Conservation Scores

Given thousands of proteins constituting a eukaryotic pathogen, the principal objective for a high-throughput in silico vaccine discovery pipeline is to select those proteins worthy of laboratory validation. Accurate prediction of T-cell epitopes on protein antigens is one crucial piece of evidence...

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Detalles Bibliográficos
Autores principales: Goodswen, Stephen J., Kennedy, Paul J., Ellis, John T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4278717/
https://www.ncbi.nlm.nih.gov/pubmed/25545691
http://dx.doi.org/10.1371/journal.pone.0115745

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4278717/
https://www.ncbi.nlm.nih.gov/pubmed/25545691
http://dx.doi.org/10.1371/journal.pone.0115745

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