A Novel Cryptic Binding Motif, LRSKSRSFQVSDEQY, in the C-Terminal Fragment of MMP-3/7-Cleaved Osteopontin as a Novel Ligand for α9β1 Integrin Is Involved in the Anti-Type II Collagen Antibody-Induced Arthritis

Osteopontin (OPN) is a multifunctional protein that has been linked to various intractable inflammatory diseases. One way by which OPN induces inflammation is the production of various functional fragments by enzyme cleavage. It has been well appreciated that OPN is cleaved by thrombin, and/or matri...

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Detalles Bibliográficos
Autores principales: Kon, Shigeyuki, Nakayama, Yosuke, Matsumoto, Naoki, Ito, Koyu, Kanayama, Masashi, Kimura, Chiemi, Kouro, Hitomi, Ashitomi, Dai, Matsuda, Tadashi, Uede, Toshimitsu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4278882/
https://www.ncbi.nlm.nih.gov/pubmed/25545242
http://dx.doi.org/10.1371/journal.pone.0116210

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4278882/
https://www.ncbi.nlm.nih.gov/pubmed/25545242
http://dx.doi.org/10.1371/journal.pone.0116210

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