An HIV-1 Envelope Immunogen with W427S Mutation in CD4 Binding Site Induced More T Follicular Helper Memory Cells and Reduced Non-Specific Antibody Responses

The CD4 binding site (CD4BS) of the HIV-1 envelope glycoprotein (Env) contains epitopes for broadly neutralizing antibody (nAb) and is the target for the vaccine development. However, the CD4BS core including residues 425-430 overlaps the B cell superantigen site and may be related to B cell exhaust...

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Detalles Bibliográficos
Autores principales: Yu, Hao-Tong, Tian, Dan, Wang, Jia-Ye, Guo, Cai-Xia, Li, Yan, Wang, Xin, Li, Di, Zhang, Feng-Min, Zhuang, Min, Ling, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4278894/
https://www.ncbi.nlm.nih.gov/pubmed/25546013
http://dx.doi.org/10.1371/journal.pone.0115047

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4278894/
https://www.ncbi.nlm.nih.gov/pubmed/25546013
http://dx.doi.org/10.1371/journal.pone.0115047

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