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Cholesterol-mediated activation of acid sphingomyelinase disrupts autophagy in the retinal pigment epithelium
Autophagy is an essential mechanism for clearing damaged organelles and proteins within the cell. As with neurodegenerative diseases, dysfunctional autophagy could contribute to blinding diseases such as macular degeneration. However, precisely how inefficient autophagy promotes retinal damage is un...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The American Society for Cell Biology
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4279221/ https://www.ncbi.nlm.nih.gov/pubmed/25378587 http://dx.doi.org/10.1091/mbc.E14-05-1028 |