Cargando…

Cholesterol-mediated activation of acid sphingomyelinase disrupts autophagy in the retinal pigment epithelium

Autophagy is an essential mechanism for clearing damaged organelles and proteins within the cell. As with neurodegenerative diseases, dysfunctional autophagy could contribute to blinding diseases such as macular degeneration. However, precisely how inefficient autophagy promotes retinal damage is un...

Descripción completa

Detalles Bibliográficos
Autores principales:	Toops, Kimberly A., Tan, Li Xuan, Jiang, Zhichun, Radu, Roxana A., Lakkaraju, Aparna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2015
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4279221/ https://www.ncbi.nlm.nih.gov/pubmed/25378587 http://dx.doi.org/10.1091/mbc.E14-05-1028

Ejemplares similares

Analysis of mitochondrial dynamics and function in the retinal pigment epithelium by high-speed high-resolution live imaging
por: Tan, Li Xuan, et al.
Publicado: (2022)

Let’s play a game of chutes and ladders: Lysosome fusion with the epithelial plasma membrane
por: Toops, Kimberly A., et al.
Publicado: (2013)

Membrane Attack Complex Mediates Retinal Pigment Epithelium Cell Death in Stargardt Macular Degeneration
por: Ng, Eunice Sze Yin, et al.
Publicado: (2022)

Abnormal mTORC1 signaling leads to retinal pigment epithelium degeneration
por: Huang, Jiancheng, et al.
Publicado: (2019)

Expression of ABCA4 in the retinal pigment epithelium and its implications for Stargardt macular degeneration
por: Lenis, Tamara L., et al.
Publicado: (2018)

Mitochondria-dependent phase separation of disease-relevant proteins drives pathological features of age-related macular degeneration
por: La Cunza, Nilsa, et al.
Publicado: (2021)

Autophagy resists EMT process to maintain retinal pigment epithelium homeostasis
por: Feng, Hao, et al.
Publicado: (2019)

Autophagy in the retinal pigment epithelium: a new vision and future challenges
por: Intartaglia, Daniela, et al.
Publicado: (2021)

Evaluation of focal damage in the retinal pigment epithelium layer in serous retinal pigment epithelium detachment
por: Miura, Masahiro, et al.
Publicado: (2019)

Prominin-1 Is a Novel Regulator of Autophagy in the Human Retinal Pigment Epithelium
por: Bhattacharya, Sujoy, et al.
Publicado: (2017)

Translocation of the retinal pigment epithelium and formation of sub-retinal pigment epithelium deposit induced by subretinal deposit
por: Zhao, Lian, et al.
Publicado: (2007)

Diacylglycerol O-Acyltransferase Type-1 Synthesizes Retinyl Esters in the Retina and Retinal Pigment Epithelium
por: Kaylor, Joanna J., et al.
Publicado: (2015)

Primary Cilium-Mediated Retinal Pigment Epithelium Maturation Is Disrupted in Ciliopathy Patient Cells
por: May-Simera, Helen Louise, et al.
Publicado: (2018)

Setting Eyes on the Retinal Pigment Epithelium
por: Moreno-Marmol, Tania, et al.
Publicado: (2018)

Functions and Diseases of the Retinal Pigment Epithelium
por: Yang, Song, et al.
Publicado: (2021)

Bestrophin 2 is expressed in human non-pigmented ciliary epithelium but not retinal pigment epithelium
por: Zhang, Youwen, et al.
Publicado: (2010)

Detection of Retinal Pigment Epithelium-Specific Antibody in iPSC-Derived Retinal Pigment Epithelium Transplantation Models
por: Sugita, Sunao, et al.
Publicado: (2017)

Impact of drusen and drusenoid retinal pigment epithelium elevation size and structure on the integrity of the retinal pigment epithelium layer
por: Schlanitz, Ferdinand, et al.
Publicado: (2019)

Common clinical features of unilateral retinal pigment epithelium dysgenesis and combined hamartoma of the retina and retinal pigment epithelium
por: Zhu, Zhe, et al.
Publicado: (2022)

Characterization of the retinal pigment epithelium in Friedreich ataxia
por: Crombie, Duncan E., et al.
Publicado: (2015)

Stem Cell Derived Retinal Pigment Epithelium: The Role of Pigmentation as Maturation Marker and Gene Expression Profile Comparison with Human Endogenous Retinal Pigment Epithelium.
por: Bennis, A., et al.
Publicado: (2017)

Inhibition of Autophagy Suppresses Sertraline-Mediated Primary Ciliogenesis in Retinal Pigment Epithelium Cells
por: Kim, Eun Sung, et al.
Publicado: (2015)

Role of retinal pigment epithelium‐derived exosomes and autophagy in new blood vessel formation
por: Atienzar‐Aroca, Sandra, et al.
Publicado: (2018)

Autophagy regulates death of retinal pigment epithelium cells in age-related macular degeneration
por: Kaarniranta, Kai, et al.
Publicado: (2016)

Suppressor of Cytokine Signaling 2 Regulates Retinal Pigment Epithelium Metabolism by Enhancing Autophagy
por: Liu, Xi-Yuan, et al.
Publicado: (2021)

Impairing autophagy in retinal pigment epithelium leads to inflammasome activation and enhanced macrophage-mediated angiogenesis
por: Liu, Jian, et al.
Publicado: (2016)

Reprogramming of the chick retinal pigmented epithelium after retinal injury
por: Luz-Madrigal, Agustin, et al.
Publicado: (2014)

Components of the cytoskeleton in the retinal pigmented epithelium of the chick
Publicado: (1985)

Retinal Pigment Epithelium Derived Stem Cells
por: Hiscott, Paul, et al.
Publicado: (2009)

Retinal pigment epithelium changes in Kartagener syndrome
por: Garcia, Maria D., et al.
Publicado: (2018)

Simple Congenital Hamartoma of the Retinal Pigment Epithelium
por: Nakatsuka, Austin S., et al.
Publicado: (2020)

Circadian Regulation of Retinal Pigment Epithelium Function
por: Baba, Kenkichi, et al.
Publicado: (2022)

Hormetic Heat Shock Enhances Autophagy through HSF1 in Retinal Pigment Epithelium Cells
por: Amirkavei, Mooud, et al.
Publicado: (2022)

Phagocytosis by the Retinal Pigment Epithelium: Recognition, Resolution, Recycling
por: Kwon, Whijin, et al.
Publicado: (2020)

Involvement of the Retinal Pigment Epithelium in the Development of Retinal Lattice Degeneration
por: Mizuno, Hiroshi, et al.
Publicado: (2020)

Shared Features in Retinal Disorders With Involvement of Retinal Pigment Epithelium
por: Sparrow, Janet R., et al.
Publicado: (2021)

Retinal Pigment Epithelium Remodeling in Mouse Models of Retinitis Pigmentosa
por: Napoli, Debora, et al.
Publicado: (2021)

Transcriptome Profiling of Embryonic Retinal Pigment Epithelium Reprogramming
por: Tangeman, Jared A., et al.
Publicado: (2021)

Mitochondrial Ceramide Effects on the Retinal Pigment Epithelium in Diabetes
por: Levitsky, Yan, et al.
Publicado: (2020)

Activation of Lysosomal Function Ameliorates Amyloid-β-Induced Tight Junction Disruption in the Retinal Pigment Epithelium
por: Jo, Dong Hyun, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_9gvpuirpn2cj6kovpciu5hfqf4