The ubiquitin E3 ligase ITCH enhances breast tumor progression by inhibiting the Hippo tumor suppressor pathway

The Hippo kinase pathway is emerging as a conserved signaling pathway that is essential for organ growth and tumorigenesis. Recently, we reported that the ubiquitin E3 ligase ITCH negatively regulates LATS1, thereby increasing YAP activity, which leads to increased cell proliferation and decreased a...

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Detalles Bibliográficos
Autores principales: Salah, Zaidoun, Itzhaki, Ella, Aqeilan, Rami I
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4279417/
https://www.ncbi.nlm.nih.gov/pubmed/25350971

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4279417/
https://www.ncbi.nlm.nih.gov/pubmed/25350971

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