mTORC2 modulates feedback regulation of p38 MAPK activity via DUSP10/MKP5 to confer differential responses to PP242 in glioblastoma

Dual-specificity phosphatases (DUSPs) dephosphorylate MAP kinases (MAPKs) resulting in their inactivation. Activation of MAPK signaling leads to enhanced DUSP expression, thus establishing feedback regulation of the MAPK pathway. The DUSPs are subject to regulation at the post-translational level vi...

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Detalles Bibliográficos
Autores principales: Benavides-Serrato, Angelica, Anderson, Lauren, Holmes, Brent, Cloninger, Cheri, Artinian, Nicholas, Bashir, Tariq, Gera, Joseph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4279437/
https://www.ncbi.nlm.nih.gov/pubmed/25568665

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4279437/
https://www.ncbi.nlm.nih.gov/pubmed/25568665

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