DEPTOR is linked to a TORC1-p21 survival proliferation pathway in multiple myeloma cells

We investigated the mechanism by which gene silencing of the mTOR inhibitor, DEPTOR, induces cytoreductive effects on multiple myeloma (MM) cells. DEPTOR knockdown resulted in anti-MM effects in several MM cell lines. Using an inducible shRNA to silence DEPTOR, 8226 MM cells underwent TORC1 activati...

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Detalles Bibliográficos
Autores principales: Yang, Yonghui, Bardeleben, Carolyne, Frost, Patrick, Hoang, Bao, Shi, Yijiang, Finn, Richard, Gera, Joseph, Lichtenstein, Alan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4279438/
https://www.ncbi.nlm.nih.gov/pubmed/25568666

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4279438/
https://www.ncbi.nlm.nih.gov/pubmed/25568666

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