HOP2-MND1 modulates RAD51 binding to nucleotides and DNA

The HOP2-MND1 heterodimer is required for progression of homologous recombination in eukaryotes. In vitro, HOP2-MND1 stimulates the DNA strand exchange activities of RAD51 and DMC1. We demonstrate that HOP2-MND1 induces changes in the conformation of RAD51 that profoundly alter the basic properties...

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Detalles Bibliográficos
Autores principales: Bugreev, Dmitry V., Huang, Fei, Mazina, Olga M., Pezza, Roberto J., Voloshin, Oleg N., Camerini-Otero, R. Daniel, Mazin, Alexander V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4279451/
https://www.ncbi.nlm.nih.gov/pubmed/24943459
http://dx.doi.org/10.1038/ncomms5198

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4279451/
https://www.ncbi.nlm.nih.gov/pubmed/24943459
http://dx.doi.org/10.1038/ncomms5198

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