A Structural Switch between Agonist and Antagonist Bound Conformations for a Ligand-Optimized Model of the Human Aryl Hydrocarbon Receptor Ligand Binding Domain

The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that regulates the expression of a diverse group of genes. Exogenous AHR ligands include the environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), which is a potent agonist, and the synthetic AHR antagonis...

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Detalles Bibliográficos
Autores principales: Perkins, Arden, Phillips, Jessica L., Kerkvliet, Nancy I., Tanguay, Robert L., Perdew, Gary H., Kolluri, Siva K., Bisson, William H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4280506/
https://www.ncbi.nlm.nih.gov/pubmed/25329374
http://dx.doi.org/10.3390/biology3040645

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4280506/
https://www.ncbi.nlm.nih.gov/pubmed/25329374
http://dx.doi.org/10.3390/biology3040645

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