Direct Activation of Ribosome-Associated Double-Stranded RNA-Dependent Protein Kinase (PKR) by Deoxynivalenol, Anisomycin and Ricin: A New Model for Ribotoxic Stress Response Induction

Double-stranded RNA (dsRNA)-activated protein kinase (PKR) is a critical upstream mediator of the ribotoxic stress response (RSR) to the trichothecene deoxynivalenol (DON) and other translational inhibitors. Here, we employed HeLa cell lysates to: (1) characterize PKR’s interactions with the ribosom...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhou, Hui-Ren, He, Kaiyu, Landgraf, Jeff, Pan, Xiao, Pestka, James J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4280541/
https://www.ncbi.nlm.nih.gov/pubmed/25521494
http://dx.doi.org/10.3390/toxins6123406

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4280541/
https://www.ncbi.nlm.nih.gov/pubmed/25521494
http://dx.doi.org/10.3390/toxins6123406

Ejemplares similares