Screening and classifying small molecule inhibitors of amyloid formation using ion mobility spectrometry-mass spectrometry

The search for therapeutic agents which bind specifically to precursor protein conformations and inhibit amyloid assembly is an important challenge. Identifying such inhibitors is difficult since many protein precursors of aggregation are partially folded or intrinsically disordered, ruling out stru...

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Detalles Bibliográficos
Autores principales: Young, Lydia M., Saunders, Janet C., Mahood, Rachel A., Revill, Charlotte H., Foster, Richard J., Tu, Ling-Hsien, Raleigh, Daniel P., Radford, Sheena E., Ashcroft, Alison E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4280571/
https://www.ncbi.nlm.nih.gov/pubmed/25515893
http://dx.doi.org/10.1038/nchem.2129

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4280571/
https://www.ncbi.nlm.nih.gov/pubmed/25515893
http://dx.doi.org/10.1038/nchem.2129

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