Sphingosine 1-phosphate to p38 signaling via S1P(1) receptor and Gαi/o evokes augmentation of capsaicin-induced ionic currents in mouse sensory neurons

The perception of painful thermal stimuli by sensory neurons is largely mediated by TRPV1. Upon tissue injury or inflammation, S1P is secreted by thrombocytes as part of an inflammatory cocktail, which sensitizes nociceptive neurons towards thermal stimuli. S1P acts on G-protein coupled receptors th...

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Detalles Bibliográficos
Autores principales: Langeslag, Michiel, Quarta, Serena, Leitner, Michael G, Kress, Michaela, Mair, Norbert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4280769/
https://www.ncbi.nlm.nih.gov/pubmed/25431213
http://dx.doi.org/10.1186/1744-8069-10-74

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4280769/
https://www.ncbi.nlm.nih.gov/pubmed/25431213
http://dx.doi.org/10.1186/1744-8069-10-74

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