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Sphingosine 1-phosphate to p38 signaling via S1P(1) receptor and Gαi/o evokes augmentation of capsaicin-induced ionic currents in mouse sensory neurons
The perception of painful thermal stimuli by sensory neurons is largely mediated by TRPV1. Upon tissue injury or inflammation, S1P is secreted by thrombocytes as part of an inflammatory cocktail, which sensitizes nociceptive neurons towards thermal stimuli. S1P acts on G-protein coupled receptors th...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4280769/ https://www.ncbi.nlm.nih.gov/pubmed/25431213 http://dx.doi.org/10.1186/1744-8069-10-74 |