Diazido Mixed-Amine Platinum(IV) Anticancer Complexes Activatable by Visible-Light Form Novel DNA Adducts

Platinum diam(m)ine complexes, such as cisplatin, are successful anticancer drugs, but suffer from problems of resistance and side-effects. Photoactivatable Pt(IV) prodrugs offer the potential of targeted drug release and new mechanisms of action. We report the synthesis, X-ray crystallographic and...

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Detalles Bibliográficos
Autores principales: Zhao, Yao, Woods, Julie A, Farrer, Nicola J, Robinson, Kim S, Pracharova, Jitka, Kasparkova, Jana, Novakova, Olga, Li, Huilin, Salassa, Luca, Pizarro, Ana M, Clarkson, Guy J, Song, Lijiang, Brabec, Viktor, Sadler, Peter J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2013
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4280898/
https://www.ncbi.nlm.nih.gov/pubmed/23733242
http://dx.doi.org/10.1002/chem.201300374

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4280898/
https://www.ncbi.nlm.nih.gov/pubmed/23733242
http://dx.doi.org/10.1002/chem.201300374

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