A narrow repertoire of transcriptional modules responsive to pyogenic bacteria is impaired in patients carrying loss-of-function mutations in MYD88 or IRAK4

Loss of function in the kinase IRAK-4 or the adapter MyD88 in humans interrupts a pathway critical for pathogen sensing and ignition of inflammation. Yet patients with loss of function mutations are surprisingly only susceptible to a limited range of pathogens. We employed a systems approach to inve...

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Detalles Bibliográficos
Autores principales: Alsina, L, Israelsson, E, Altman, MC, Dang, KK, Ghandil, P, Israel, L, von Bernuth, H, Baldwin, N, Qin, H, Jin, Z, Banchereau, R, Anguiano, E, Ionan, A, Abel, L, Puel, A, Picard, C, Pascual, V, Casanova, JL, Chaussabel, D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4281021/
https://www.ncbi.nlm.nih.gov/pubmed/25344726
http://dx.doi.org/10.1038/ni.3028

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4281021/
https://www.ncbi.nlm.nih.gov/pubmed/25344726
http://dx.doi.org/10.1038/ni.3028

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