Intratracheal Instillation of High Dose Adenoviral Vectors Is Sufficient to Induce Lung Injury and Fibrosis in Mice

RATIONALE: Replication deficient adenoviruses (Ad) vectors are common tools in gene therapy. Since Ad vectors are known to activate innate and adaptive immunity, we investigated whether intratracheal administration of Ad vectors alone is sufficient to induce lung injury and pulmonary fibrosis. METHO...

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Detalles Bibliográficos
Autores principales: Zhou, Qiyuan, Chen, Tianji, Bozkanat, Melike, Ibe, Joyce Christina F., Christman, John W., Raj, J. Usha, Zhou, Guofei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4281082/
https://www.ncbi.nlm.nih.gov/pubmed/25551570
http://dx.doi.org/10.1371/journal.pone.0116142

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4281082/
https://www.ncbi.nlm.nih.gov/pubmed/25551570
http://dx.doi.org/10.1371/journal.pone.0116142

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