Design of Chemically Stable, Potent, and Efficacious MDM2 Inhibitors That Exploit the Retro-Mannich Ring-Opening-Cyclization Reaction Mechanism in Spiro-oxindoles

[Image: see text] Inhibition of the MDM2–p53 protein–protein interaction is being actively pursued as a new anticancer therapeutic strategy, and spiro-oxindoles have been designed as a class of potent and efficacious small-molecule inhibitors of this interaction (MDM2 inhibitors). Our previous study...

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Detalles Bibliográficos
Autores principales: Aguilar, Angelo, Sun, Wei, Liu, Liu, Lu, Jianfeng, McEachern, Donna, Bernard, Denzil, Deschamps, Jeffrey R., Wang, Shaomeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4281096/
https://www.ncbi.nlm.nih.gov/pubmed/25496041
http://dx.doi.org/10.1021/jm501541j

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4281096/
https://www.ncbi.nlm.nih.gov/pubmed/25496041
http://dx.doi.org/10.1021/jm501541j

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