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Synthesis and κ-Opioid Receptor Activity of Furan-Substituted Salvinorin A Analogues

[Image: see text] The neoclerodane diterpene salvinorin A, found in the leaves of Salvia divinorum, is a potent κ-opioid receptor agonist, making it an attractive scaffold for development into a treatment for substance abuse. Although several successful semisynthetic studies have been performed to e...

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Detalles Bibliográficos
Autores principales: Riley, Andrew P., Groer, Chad E., Young, David, Ewald, Amy W., Kivell, Bronwyn M., Prisinzano, Thomas E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4281103/
https://www.ncbi.nlm.nih.gov/pubmed/25426797
http://dx.doi.org/10.1021/jm501521d