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The Proteomic and Genomic Teratogenicity Elicited by Valproic Acid Is Preventable with Resveratrol and α-Tocopherol

BACKGROUND: Previously, we reported that valproic acid (VPA), a common antiepileptic drug and a potent teratogenic, dowregulates RBP4 in chicken embryo model (CEM) when induced by VPA. Whether such teratogenicity is associated with more advanced proteomic and genomic alterations, we further performe...

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Detalles Bibliográficos
Autores principales: Chen, Yeh, Lin, Ping-Xiao, Hsieh, Chiu-Lan, Peng, Chiung-Chi, Peng, Robert Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4281235/
https://www.ncbi.nlm.nih.gov/pubmed/25551574
http://dx.doi.org/10.1371/journal.pone.0116534