Potassium Channel Antagonists 4-Aminopyridine and the T-Butyl Carbamate Derivative of 4-Aminopyridine Improve Hind Limb Function in Chronically Non-Ambulatory Dogs; A Blinded, Placebo-Controlled Trial

4-Aminopyridine (4-AP) blocks voltage gated potassium channels, restoring conduction to demyelinated axons and improving function in demyelinating conditions, but its use is associated with adverse effects and benefit in spinal cord injury is limited. Derivatives of 4-AP have been developed to impro...

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Detalles Bibliográficos
Autores principales: Lim, Ji-Hey, Muguet-Chanoit, Audrey C., Smith, Daniel T., Laber, Eric, Olby, Natasha J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4281252/
https://www.ncbi.nlm.nih.gov/pubmed/25551385
http://dx.doi.org/10.1371/journal.pone.0116139

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4281252/
https://www.ncbi.nlm.nih.gov/pubmed/25551385
http://dx.doi.org/10.1371/journal.pone.0116139

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