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Stably paused genes revealed through inhibition of transcription initiation by the TFIIH inhibitor triptolide

Transcription by RNA polymerase II (Pol II) in metazoans is regulated in several steps, including preinitiation complex (PIC) formation, initiation, Pol II escape, productive elongation, cotranscriptional RNA processing, and termination. Genome-wide studies have demonstrated that the phenomenon of p...

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Detalles Bibliográficos
Autores principales: Chen, Fei, Gao, Xin, Shilatifard, Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4281563/
https://www.ncbi.nlm.nih.gov/pubmed/25561494
http://dx.doi.org/10.1101/gad.246173.114