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N-terminal acetylation and replicative age affect proteasome localization and cell fitness during aging

Specific degradation of proteins is essential for virtually all cellular processes and is carried out predominantly by the proteasome. The proteasome is important for clearance of damaged cellular proteins. Damaged proteins accumulate over time and excess damaged proteins can aggregate and induce th...

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Detalles Bibliográficos
Autores principales: van Deventer, Sjoerd, Menendez-Benito, Victoria, van Leeuwen, Fred, Neefjes, Jacques
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4282048/
https://www.ncbi.nlm.nih.gov/pubmed/25413350
http://dx.doi.org/10.1242/jcs.157354