FISHER'S GEOMETRIC MODEL OF ADAPTATION MEETS THE FUNCTIONAL SYNTHESIS: DATA ON PAIRWISE EPISTASIS FOR FITNESS YIELDS INSIGHTS INTO THE SHAPE AND SIZE OF PHENOTYPE SPACE

The functional synthesis uses experimental methods from molecular biology, biochemistry and structural biology to decompose evolutionarily important mutations into their more proximal mechanistic determinants. However these methods are technically challenging and expensive. Noting strong formal para...

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Detalles Bibliográficos
Autores principales: Weinreich, Daniel M, Knies, Jennifer L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2013
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4282100/
https://www.ncbi.nlm.nih.gov/pubmed/24094346
http://dx.doi.org/10.1111/evo.12156

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4282100/
https://www.ncbi.nlm.nih.gov/pubmed/24094346
http://dx.doi.org/10.1111/evo.12156

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