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Maximum type 1 error rate inflation in multiarmed clinical trials with adaptive interim sample size modifications
Sample size modifications in the interim analyses of an adaptive design can inflate the type 1 error rate, if test statistics and critical boundaries are used in the final analysis as if no modification had been made. While this is already true for designs with an overall change of the sample size i...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BlackWell Publishing Ltd
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4282114/ https://www.ncbi.nlm.nih.gov/pubmed/24753160 http://dx.doi.org/10.1002/bimj.201300153 |