An activin receptor IIA ligand trap promotes erythropoiesis resulting in a rapid induction of red blood cells and haemoglobin

Sotatercept (ACE-011), a recombinant human fusion protein containing the extracellular domain of the human Activin receptor IIA, binds to and inhibits activin and other members of the transforming growth factor -β (TGF-β) superfamily. Administration of sotatercept led to a rapid and sustained increa...

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Detalles Bibliográficos
Autores principales: Carrancio, Soraya, Markovics, Jennifer, Wong, Piu, Leisten, Jim, Castiglioni, Paola, Groza, Matthew C, Raymon, Heather K, Heise, Carla, Daniel, Tom, Chopra, Rajesh, Sung, Victoria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Red Cells and Iron
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4282119/
https://www.ncbi.nlm.nih.gov/pubmed/24635723
http://dx.doi.org/10.1111/bjh.12838

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4282119/
https://www.ncbi.nlm.nih.gov/pubmed/24635723
http://dx.doi.org/10.1111/bjh.12838

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