The MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in response to cytokines

Unlike the other MAP3Ks, MEKK1 (encoded by Map3k1) contains a PHD motif. To understand the role of this motif, we have created a knockin mutant of mouse Map3k1 (Map3k1(m)(PHD)) with an inactive PHD motif. Map3k1(m)(PHD) ES cells demonstrate that the MEKK1 PHD controls p38 and JNK activation during T...

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Detalles Bibliográficos
Autores principales: Charlaftis, Nikolaos, Suddason, Tesha, Wu, Xuefeng, Anwar, Saba, Karin, Michael, Gallagher, Ewen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4282369/
https://www.ncbi.nlm.nih.gov/pubmed/25260751
http://dx.doi.org/10.15252/embj.201488351

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4282369/
https://www.ncbi.nlm.nih.gov/pubmed/25260751
http://dx.doi.org/10.15252/embj.201488351

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