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The MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in response to cytokines

Unlike the other MAP3Ks, MEKK1 (encoded by Map3k1) contains a PHD motif. To understand the role of this motif, we have created a knockin mutant of mouse Map3k1 (Map3k1(m)(PHD)) with an inactive PHD motif. Map3k1(m)(PHD) ES cells demonstrate that the MEKK1 PHD controls p38 and JNK activation during T...

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Detalles Bibliográficos
Autores principales:	Charlaftis, Nikolaos, Suddason, Tesha, Wu, Xuefeng, Anwar, Saba, Karin, Michael, Gallagher, Ewen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BlackWell Publishing Ltd 2014
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4282369/ https://www.ncbi.nlm.nih.gov/pubmed/25260751 http://dx.doi.org/10.15252/embj.201488351

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