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Comparing the Efficacy of SNP Filtering Methods for Identifying a Single Causal SNP in a Known Association Region

Genome-wide association studies have successfully identified associations between common diseases and a large number of single nucleotide polymorphisms (SNPs) across the genome. We investigate the effectiveness of several statistics, including p-values, likelihoods, genetic map distance and linkage...

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Detalles Bibliográficos
Autores principales: Spencer, Amy Victoria, Cox, Angela, Walters, Kevin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4282378/
https://www.ncbi.nlm.nih.gov/pubmed/24205929
http://dx.doi.org/10.1111/ahg.12043