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Population shift of binding pocket size and dynamic correlation analysis shed new light on the anticooperative mechanism of P(II) protein

P(II) protein is one of the largest families of signal transduction proteins in archaea, bacteria, and plants, controlling key processes of nitrogen assimilation. An intriguing characteristic for many P(II) proteins is that the three ligand binding sites exhibit anticooperative allosteric regulation...

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Detalles Bibliográficos
Autores principales: Ma, Cheng-Wei, Lüddecke, Jan, Forchhammer, Karl, Zeng, An-Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4282546/
https://www.ncbi.nlm.nih.gov/pubmed/24218085
http://dx.doi.org/10.1002/prot.24477