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An Efficient Method for the In Vitro Production of Azol(in)e-Based Cyclic Peptides
Heterocycle-containing cyclic peptides are promising scaffolds for the pharmaceutical industry but their chemical synthesis is very challenging. A new universal method has been devised to prepare these compounds by using a set of engineered marine-derived enzymes and substrates obtained from a famil...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
WILEY-VCH Verlag
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4282754/ https://www.ncbi.nlm.nih.gov/pubmed/25331823 http://dx.doi.org/10.1002/anie.201408082 |